Agent Information
The I-SPY Program is committed to open science, through timely publication and release of results, and ultimately data, from all arms of our trials.
MK2206 is an orally available, allosteric small-molecule inhibitor of AKT, In pre-clinical models, MK-2206 was shown to bind to and inhibit the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. MK-2206 can inhibit tumor cell proliferation and induce apoptosis (cell death) in some of those models.