Manuscripts

The I-SPY Program is committed to open science, through timely publication and release of results, and ultimately data, from all arms of our trials.

Featured Publications

Published Manuscripts

Olshen A, Wolf D, Jones EF, et al.
Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL
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J Med Imaging
5
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11014
2018
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abstract
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Severson TM, Wolf DM, Yau C, et al.
The BRCA1 ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting
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Breast Cancer Res
19
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99
2017
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abstract
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Wolf DM, Yau C, Sanil A, et al.
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial
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npj Breast Cancer
3
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2017
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abstract
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Campbell JI, Yau C, Krass P, et al.
Comparison of residual cancer burden, American Joint Committee on Cancer staging and pathologic complete response in breast cancer after neoadjuvant chemotherapy: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).
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Breast Cancer Res Treat
165
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181-191
2017
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abstract
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Li W, Arasu V, Newitt DC, et al.
Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL.
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Tomography
2
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378-387
2016
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abstract
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Rugo HS, Olopade, OI, DeMichele A, et al.
Adaptive randomization of veliparib-carboplatin treatment in breast cancer
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New Engl J Med
375
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23-34
2016
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abstract
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Park JW, Liu MC, Yee D, et al.
Adaptive Randomization of Neratinib in Early Breast Cancer.
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N Engl J Med
375
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11-22
2016
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abstract
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Magbanua MJM, Wolf DM, Yau C, et al.
Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response
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Breast Cancer Res
17
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73
2015
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abstract
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DeMichele, Angela,Yee, Douglas,Berry, Donald A, et al.
The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer.
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Clinical Cancer Research
21
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2911-2915
2015
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abstract
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Clark AS, Chen J, Kapoor S, et al.
Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I‐SPY trial (CALGB 150007/150015/ACRIN6657)
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Cancer Medicine
3
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693-701
2014
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abstract
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Cureton EL, Yau C, Alvarado MD, et al.
Local Recurrence Rates are Low in High-Risk Neoadjuvant Breast Cancer in the I-SPY 1 Trial (CALGB 150007/150012; ACRIN 6657)
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Ann Surg Oncol
21
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2889-2896
2014
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abstract
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Alvarez JV, Pan T-C, Ruth J, et al.
Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy
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Cancer Cell
24
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30-44
2013
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abstract
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Mukhtar RA, Yau C, Rosen M, et al.
Clinically Meaningful Tumor Reduction Rates Vary by Prechemotherapy MRI Phenotype and Tumor Subtype in the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)
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Ann Surg Oncol
20
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3823-3830
2013
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abstract
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DeMichele A, Berry DA, Zujewski J, et al.
Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
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Clinical Cancer Research
19
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2817-2823
2013
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abstract
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Glück S, de Snoo F, Peeters J, et al.
Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy.
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Breast Cancer Res Treat
139
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759-767
2013
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abstract
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Yee D, Haddad T, Albain K, et al.
Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development [Correspondence]
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J. Clin. Oncol.
30
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Jun-84
2012
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abstract
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Esserman LJ, Barker AD, Woodcock J, et al.
A Model for Accelerating Identification and Regulatory Approval of Effective Investigational Agents
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Cureus
4
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e76
2012
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abstract
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Wulfkuhle JD, Berg D, Wolff C, et al.
Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping
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Clinical Cancer Research
18
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6426-6435
2012
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abstract
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Esserman LJ, Berry DA, DeMichele A, et al.
Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657.
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J Clin Oncol
30
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3242-3249
2012
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abstract
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Lips EH, Mukhtar RA, Yau C, et al.
Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer
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Breast Cancer Res Treat
136
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35-43
2012
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abstract
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Hylton NM, Blume JD, Bernreuter WK, et al.
Locally Advanced Breast Cancer: MR Imaging for Prediction of Response to Neoadjuvant Chemotherapy—Results from ACRIN 6657/I-SPY TRIAL
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Radiology
263
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663-672
2012
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abstract
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Esserman LJ, Berry DA, Cheang MCU, et al.
Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).
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Breast Cancer Res Treat
132
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1049-1062
2012
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abstract
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Lin C, Buxton MB, Moore D, et al.
Locally advanced breast cancers are more likely to present as Interval Cancers: results from the I-SPY 1 TRIAL (CALGB 150007/150012, ACRIN 6657, InterSPORE Trial).
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Breast Cancer Res Treat
132
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871-879
2012
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abstract
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Esserman LJ, Woodcock J
Accelerating identification and regulatory approval of investigational cancer drugs.
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JAMA
306
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2608-2609
2011
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abstract
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Barker AD, Sigman CC, Kelloff GJ, et al.
I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy.
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Clinical Pharmacol & Therapeutics
86
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97-100
2009
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abstract
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