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I-SPY Data

Widely hailed as the future of phase II drug development, the adaptive I-SPY2 platform trial has set a new benchmark for efficiency, through innovation in trial design and clinical operations.

Coming Soon...

I-SPY990 Data Resource
The I-SPY-990 data resource contains gene expression, protein/phospho-protein and clinical data for the first 990 patients enrolled in I-SPY2 across nine experimental treatment arms (plus the control arm). All patients have pre-treatment full transcriptome gene expression data assayed on Agilent 44K (GPL16233; n=333) or 32K (GPL20078; n=654) microarrays, which has been normalized and combined over the two array types into a single dataset of 19,134 genes from 987 patients. 736 patients (all arms except ganitumab and ganetespib) have normalized LCM-RPPA data combined across 3 arrays for 140 proteins and phospho-proteins representing key signaling proteins and drug targets in cancer pathways including cell cycle, AKT/mTOR, immune, receptor tyrosine kinases, and others. Clinical data includes HR, HER2 and MP status, response (pCR or no pCR), and treatment arm.  The ISPY2-990 Data Resource will be made publicly available in NCBI's Gene Expression Omnibus (GEO) repository.

The data will be released with the publication of a manuscript currently in review: 
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: predictive biomarkers across 9 targeted therapies
Denise M Wolf, et al.


I-SPY2 Agents

The I-SPY2 Trial's ground-breaking adaptive, multi-agent design allows up to five agents (or combinations of agents) to be evaluated in parallel. Click on an agent of interest to view more information about the agent and the results obtained in I-SPY. Agents in the table below are ordered newest to oldest beast upon date of entry into the study.
Agent(s)
Status
Currently Enrolling
Currently Enrolling
Currently Enrolling
Currently Enrolling
Currently Enrolling
Currently Enrolling
Completed (Results Pending)
Completed (Results Pending)
Graduated
Halted for Toxicity
Stopped for Futility
Graduated
Graduated
Stopped for Futility
Stopped for Futility
Graduated
Graduated