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Agent Information

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pembrolizumab

Trade Name:
Keytruda
Company:
Merck
Status:
Graduated
Agent Chaperone(s):
Rita NandaMinetta Liu
Treatment Protocol:
Pembrolizumab is a PD-1 Inhibitor. Pembrolizumab was administered at 200 mg intravenously once every 3 weeks (q3w) with Paclitaxel administered at 80 mg/m2 weekly (q1w) for 12 total weeks. This regimen was followed by AC (q2w or q3w) for 4 weeks.
Date Entered I-SPY:
November 26, 2015
Date Left I-SPY:
November 5, 2016
No. Participants in Arm:
69
Graduating Subtypes:
HER2-, TN, HR+HER2-
Agent Description:

Pembrolizumab (Keytruda) is a humanized antibody used in cancer immunotherapy. It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1 (PD-1) receptor of lymphocytes.

Notes:
Final pCR Probabilities:
Primary Manuscript:
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abstractpdfdoi link

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